Introduction: Limbic encephalitis is a rapidly progressing disease that
presents with seizures, psychiatric symptoms, and recent memory
loss. Detection of more than one autoantibody is a rare condition in
this disease where an underlying autoantibody is frequently detected.
Although different autoantibodies have been reported in the literature,
no case has been reported regarding the association of anti-γ-
aminobutyric acid-beta-receptor (anti-GABABR) and anti-α-amino-3
hydroxy-5-methyl-4-isoxazolepropionic acid (anti-AMPAR).
Case: In this presentation, a 46-year-old female patient with subacute
development of short-term memory loss and behavioral symptoms will
be described. Anti-GABABR and anti-AMPAR were positive in the antineuronal
antibody panel sent from the cerebrospinal fluid and serum.
Small cell lung cancer was detected as a result of malignancy screening
tests. The patient’s complaints and autoantibody positivity regressed
after immunotherapy.
Conclusion: In this case report, a case with coexistence of anti-GABABR
and anti-AMPAR antibodies, which has not been previously reported in
the literature, is described. As more cases with the coexistence of these
two antibodies are detected, knowledge on clinical aspect, laboratory
and treatment will increase.
Keywords: Anti-α-amino-3 hydroxy-5-methyl-4-isoxazolepropionic
acid (anti-AMPAR), anti-γ-aminobutyric acid-beta-receptor (anti-
GABABR), Coexistence of anti-neuronal antibody, limbic encephalitis