Introduction: The present study aimed to compare the Parietal Lobe (PL)
volumes and Cancellation Test (CT) performances of euthymic patients
with Bipolar Disorder-1 (BD) and Major Depressive Disorder (MDD), and
healthy controls.
Methods: The present study included 63 participants in three groups;
two patient groups in remission involving patients with BD and MDD
diagnosed according to DSM-5 and a control group with healthy
individuals. Sociodemographic Data Form, CT, and Hand Preference
Questionnaire were applied to all participants. Participant PL volumes
were measured with the Cloud-Based Brain Magnetic Resonance Image
Segmentation – Parcellation System.
Results: Both patient groups exhibited lower PL volume when compared
to the control group, and there was no difference between the patient
groups based on PL volume. It was determined that MDD and BB
patients scored less in the CT when compared to the control group.
There was a weak correlation between right and left PL volumes and CT
performances.
Conclusion: The present study findings demonstrated that BD and MDD
patients in remission exhibited lower PL volume and CT performance
when compared to healthy controls, emphasizing that PL could be
structurally and functionally significant in the pathophysiology of mood
disorders.
Keywords: Bipolar disorder, depression, neuropsychological test,
parietal lobe volume