Highlights
Abstract
Neuromyelitis Optica spectrum disorder (NMO-SD) is a rare
demyelinating disease detected in pediatric patients affecting the
primary optic nerve and spinal cord. Clinical findings might overlap
with other demyelinating diseases and compare to particularly multiple
sclerosis the treatment regimens significantly differ. Therefore, to
establish an immediate and definite diagnosis of NMO-SD is crucial.
In the majority of patients, the aquaporin-4 antibody is detected in the
serum as one of the supporting diagnostic criteria. The antibody against
myelin oligodendrocyte glycoprotein (MOG) is recently reported to be
associated with serum aquaporin-4 antibody seronegative NMO-SD.
Although not included in the diagnostic criteria, we believe that antiMOG antibody may facilitate the diagnosis of NMO-SD. We herein report
a pediatric case of NMO-SD with the anti-MOG antibody seropositivity.
Keywords: Neuromyelitis optica spectrum disorder, Devic syndrome,
anti myelin oligodendrocyte glycoprotein antibody, aquaporin-4
antibody